U400 is designed for production of accelerated ion beams of atomic mass in the range A=4 ÷ 209 and energy 3 ÷ 29 MeV/nucleon. U400 isochronous cyclotron has been in operation since 1978 . Cyclotron is 4m in diameter, D=4 m, with K=650 energy factor. Charge exchange technique is used for beam extraction. Axial injection channel with external ion source has been in operation at U400 since 1996.